Statin Use and Gait-Speed Decline in Community-Dwelling Older Adults
Identifieur interne : 001196 ( Main/Exploration ); précédent : 001195; suivant : 001197Statin Use and Gait-Speed Decline in Community-Dwelling Older Adults
Auteurs : Wei-Hsuan Lo-Ciganic [États-Unis] ; Subashan Perera [États-Unis] ; Shelly L. Gray [États-Unis] ; Robert M. Boudreau [États-Unis] ; Janice C. Zgibor [États-Unis] ; Elsa S. Strotmeyer [États-Unis] ; Julie M. Donohue [États-Unis] ; Clareann H. Bunker [États-Unis] ; Anne B. Newman [États-Unis] ; Eleanor M. Simonsick [États-Unis] ; Douglas C. Bauer [États-Unis] ; Suzanne Satterfield [États-Unis] ; Paolo Caserotti ; Tamara Harris [États-Unis] ; Ronald I. Shorr [États-Unis] ; Joseph T. Hanlon [États-Unis]Source :
- Journal of the American Geriatrics Society [ 0002-8614 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- Composition corporelle, Démarche, Femelle, Humains, Mâle, Relation dose-effet des médicaments, Sujet âgé, Études longitudinales.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- drug effects : Gait.
- Aged, Body Composition, Dose-Response Relationship, Drug, Female, Humans, Longitudinal Studies, Male.
Abstract
The association between statin use and physical function is uncertain. The objective of this study was to examine the association between statin use and objectively assessed gait-speed decline in community-dwelling older adults.
Longitudinal cohort study.
Health, Aging, and Body Composition (Health ABC) study.
Two thousand five participants aged 70–79 years at baseline, with medication and gait speed data at years 1998–1999, 1999–2000, 2001–2002 and 2002–2003.
The independent variables were any statin use, their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was gait speed decline ≥ 0.1 m/s in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic, health-related behaviors, health status and access to health care factors.
Statin use increased from 16.2% in 1998–1999 to 25.6% in 2002–2003. The overall proportions of those with gait speed decline ≥ 0.1 m/s increased from 22.2 to 23.9% between 1998–2003. Compared to non-users, any statin use was not associated with gait speed decline ≥ 0.1 m/s (adjusted odds ratio [AOR] = 0.90, 95% CI [0.77, 1.06]). Similar non-significant trends were also seen with the use of hydrophilic or lipophilic statins. Only low-dose statin users were found to have a 22% lower risk of gait speed decline (AOR = 0.78, 95% CI [0.61, 0.99]), which was mainly driven by the results from 1999–2000 follow-up.
These results suggest no detrimental effects of statin use on gait speed decline in community-dwelling older adults.
Url:
DOI: 10.1111/jgs.13134
PubMed: 25537649
PubMed Central: 4300263
Affiliations:
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Le document en format XML
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Gray</name><affiliation wicri:level="2"><nlm:aff id="A3">School of Pharmacy, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>School of Pharmacy, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Zgibor, Janice C" sort="Zgibor, Janice C" uniqKey="Zgibor J" first="Janice C." last="Zgibor">Janice C. Zgibor</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Donohue, Julie M" sort="Donohue, Julie M" uniqKey="Donohue J" first="Julie M." last="Donohue">Julie M. Donohue</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Bunker, Clareann H" sort="Bunker, Clareann H" uniqKey="Bunker C" first="Clareann H." last="Bunker">Clareann H. Bunker</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Medicine (Geriatrics), School of Medicine, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine (Geriatrics), School of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><affiliation wicri:level="2"><nlm:aff id="A6">Intramural Research Program, National Institute on Aging, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, National Institute on Aging, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Bauer, Douglas C" sort="Bauer, Douglas C" uniqKey="Bauer D" first="Douglas C." last="Bauer">Douglas C. Bauer</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of General Medicine, School of Medicine, University of California, San Francisco, CA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of General Medicine, School of Medicine, University of California, San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Caserotti, Paolo" sort="Caserotti, Paolo" uniqKey="Caserotti P" first="Paolo" last="Caserotti">Paolo Caserotti</name><affiliation><nlm:aff id="A9">Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark</nlm:aff><wicri:noCountry code="subfield">University of Southern Denmark</wicri:noCountry></affiliation></author><author><name sortKey="Harris, Tamara" sort="Harris, Tamara" uniqKey="Harris T" first="Tamara" last="Harris">Tamara Harris</name><affiliation wicri:level="2"><nlm:aff id="A6">Intramural Research Program, National Institute on Aging, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, National Institute on Aging, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Shorr, Ronald I" sort="Shorr, Ronald I" uniqKey="Shorr R" first="Ronald I." last="Shorr">Ronald I. Shorr</name><affiliation wicri:level="2"><nlm:aff id="A10">North Florida/South Georgia Veterans Health System Geriatric Research Education and Clinical Center, Gainesville, FL</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>North Florida/South Georgia Veterans Health System Geriatric Research Education and Clinical Center, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><affiliation wicri:level="2"><nlm:aff id="A1">Center for Pharmaceutical Policy and Prescribing, School of Health Sciences, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Center for Pharmaceutical Policy and Prescribing, School of Health Sciences, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Medicine (Geriatrics), School of Medicine, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine (Geriatrics), School of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A11">Center for Health Equity Research and Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Center for Health Equity Research and Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of the American Geriatrics Society</title><idno type="ISSN">0002-8614</idno><idno type="eISSN">1532-5415</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Body Composition</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Gait (drug effects)</term><term>Humans</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage)</term><term>Longitudinal Studies</term><term>Male</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Composition corporelle</term><term>Démarche ()</term><term>Femelle</term><term>Humains</term><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (administration et posologie)</term><term>Mâle</term><term>Relation dose-effet des médicaments</term><term>Sujet âgé</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gait</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Body Composition</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Composition corporelle</term><term>Démarche</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Relation dose-effet des médicaments</term><term>Sujet âgé</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>BACKGROUND/OBJECTIVES</title><p id="P1">The association between statin use and physical function is uncertain. The objective of this study was to examine the association between statin use and objectively assessed gait-speed decline in community-dwelling older adults.</p></sec><sec id="S2"><title>DESIGN</title><p id="P2">Longitudinal cohort study.</p></sec><sec id="S3"><title>SETTING</title><p id="P3">Health, Aging, and Body Composition (Health ABC) study.</p></sec><sec id="S4"><title>PARTICIPANTS</title><p id="P4">Two thousand five participants aged 70–79 years at baseline, with medication and gait speed data at years 1998–1999, 1999–2000, 2001–2002 and 2002–2003.</p></sec><sec id="S5"><title>MEASUREMENTS</title><p id="P5">The independent variables were any statin use, their standardized daily doses (low, moderate, high) and lipophilicity. The primary outcome measure was gait speed decline ≥ 0.1 m/s in the following year of statin use. Multivariable generalized estimating equations were used, adjusting for demographic, health-related behaviors, health status and access to health care factors.</p></sec><sec id="S6"><title>RESULTS</title><p id="P6">Statin use increased from 16.2% in 1998–1999 to 25.6% in 2002–2003. The overall proportions of those with gait speed decline ≥ 0.1 m/s increased from 22.2 to 23.9% between 1998–2003. Compared to non-users, any statin use was not associated with gait speed decline ≥ 0.1 m/s (adjusted odds ratio [AOR] = 0.90, 95% CI [0.77, 1.06]). Similar non-significant trends were also seen with the use of hydrophilic or lipophilic statins. Only low-dose statin users were found to have a 22% lower risk of gait speed decline (AOR = 0.78, 95% CI [0.61, 0.99]), which was mainly driven by the results from 1999–2000 follow-up.</p></sec><sec id="S7"><title>CONCLUSION</title><p id="P7">These results suggest no detrimental effects of statin use on gait speed decline in community-dwelling older adults.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Floride</li><li>Maryland</li><li>Pennsylvanie</li><li>Tennessee</li><li>Washington (État)</li></region></list><tree><noCountry><name sortKey="Caserotti, Paolo" sort="Caserotti, Paolo" uniqKey="Caserotti P" first="Paolo" last="Caserotti">Paolo Caserotti</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Lo Ciganic, Wei Hsuan" sort="Lo Ciganic, Wei Hsuan" uniqKey="Lo Ciganic W" first="Wei-Hsuan" last="Lo-Ciganic">Wei-Hsuan Lo-Ciganic</name></region><name sortKey="Bauer, Douglas C" sort="Bauer, Douglas C" uniqKey="Bauer D" first="Douglas C." last="Bauer">Douglas C. Bauer</name><name sortKey="Boudreau, Robert M" sort="Boudreau, Robert M" uniqKey="Boudreau R" first="Robert M." last="Boudreau">Robert M. Boudreau</name><name sortKey="Bunker, Clareann H" sort="Bunker, Clareann H" uniqKey="Bunker C" first="Clareann H." last="Bunker">Clareann H. Bunker</name><name sortKey="Donohue, Julie M" sort="Donohue, Julie M" uniqKey="Donohue J" first="Julie M." last="Donohue">Julie M. Donohue</name><name sortKey="Gray, Shelly L" sort="Gray, Shelly L" uniqKey="Gray S" first="Shelly L." last="Gray">Shelly L. Gray</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Hanlon, Joseph T" sort="Hanlon, Joseph T" uniqKey="Hanlon J" first="Joseph T." last="Hanlon">Joseph T. Hanlon</name><name sortKey="Harris, Tamara" sort="Harris, Tamara" uniqKey="Harris T" first="Tamara" last="Harris">Tamara Harris</name><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><name sortKey="Newman, Anne B" sort="Newman, Anne B" uniqKey="Newman A" first="Anne B." last="Newman">Anne B. Newman</name><name sortKey="Perera, Subashan" sort="Perera, Subashan" uniqKey="Perera S" first="Subashan" last="Perera">Subashan Perera</name><name sortKey="Satterfield, Suzanne" sort="Satterfield, Suzanne" uniqKey="Satterfield S" first="Suzanne" last="Satterfield">Suzanne Satterfield</name><name sortKey="Shorr, Ronald I" sort="Shorr, Ronald I" uniqKey="Shorr R" first="Ronald I." last="Shorr">Ronald I. Shorr</name><name sortKey="Simonsick, Eleanor M" sort="Simonsick, Eleanor M" uniqKey="Simonsick E" first="Eleanor M." last="Simonsick">Eleanor M. Simonsick</name><name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name><name sortKey="Zgibor, Janice C" sort="Zgibor, Janice C" uniqKey="Zgibor J" first="Janice C." last="Zgibor">Janice C. Zgibor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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